P-Lactams in Combination with Amdinocillin
نویسندگان
چکیده
Long Island Jewish Medical Center, New Hyde Park, New York 110421; State University ofNew York at Stony Brook, Stony Brook, New York J17942; University of Connecticut Health Center, Farmington, Connecticut 060323; Clinical Microbiology Institute, Tualatin, Oregon 970624; Hoffmann-LaRoche Inc., Nutley, New Jersey 071105; Barnes Hospital and Washington University, St. Louis, Missouri 63110/6; and University of Michigan Medical Center, Ann Arbor, Michigan 481097
منابع مشابه
Penicillin-binding protein 2 inactivation in Escherichia coli results in cell division inhibition, which is relieved by FtsZ overexpression.
Aminoacyl-tRNA synthetase mutants of Escherichia coli are resistant to amdinocillin (mecillinam), a beta-lactam antibiotic which specifically binds penicillin-binding protein 2 (PBP2) and prevents cell wall elongation with concomitant cell death. The leuS(Ts) strain, in which leucyl-tRNA synthetase is temperature sensitive, was resistant to amdinocillin at 37 degrees C because of an increased g...
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تاریخ انتشار 2003